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Power, Sex, Suicide: Mitochondria and the Meaning of Life
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Audible Audiobook
Listening Length: 15 hours and 54 minutes
Program Type: Audiobook
Version: Unabridged
Publisher: Tantor Audio
Audible.com Release Date: March 12, 2019
Whispersync for Voice: Ready
Language: English, English
ASIN: B07P75DS9B
Amazon Best Sellers Rank:
I hadn’t studied much biology since my college days 50 years ago, so this exciting book was a real eye opener. How did life actually get going on earth? Why did it take a couple of billion years before all higher forms of life got their start, and how are mitochondria the key? Why would most life in other parts of the universe likely not get beyond the level of bacteria? What do mitochondria have to do with aging, and how do we age more slowly than rats but faster than birds?Renowned British scientist and author Nick Lane explores all these questions and many more, explaining the latest research, controversies, and speculations. Lane does a very good job of explaining the basic findings and arguments to educated readers who are not trained in biology but are keen to understand what’s going on inside the life they see all around and experience in their own bodies.My interests had been more in the physical and mathematical sciences, but there’s nothing like encounters with aging that will say “Whoa – What’s Going On Here?â€, especially when your doctor says, “Don’t worry, that’s just normal agingâ€. A heart attack, a detached retina, loss of balance – “just normal aging†- SURE! It’s like a SYNDROME, a name for something they don’t understand or can’t do much about. Or could they? - if they thought more like curious scientists exploring the universe and less like authorities stuck in the ruts of past dogmas.So Lane explains why all the anti-oxidant therapies in the world have failed to extend our life spans, despite the destruction wrecked by free radicals on mitochondrial DNA. Yet birds, with only a few changes to their DNA, avoid most of this damage and live disease-free to ripe old ages (relative to their body size). There is even a group of humans in Italy who live to 100 quite easily due to a simple genetic mutation. He identifies “uncoupling†as the possible mechanism as it causes the “respiration chain†in mitochondria to produce heat instead of free radicals when the mitochondria is at rest (not producing ATP to power the cell). The implication is that there may be better prospects for gene therapies than drug therapies in our future (at least if humanity somehow manages to survive the wrath of Gaia against the wanton destruction of a civilization drunk on fossil fuels).
Fascinating book about the evolution of cells and the role of mitochondria in allowing large eukaryote cells and multi-cellular organisms. Extremely clear descriptions of how things work, and an excellent framework for understanding issues in evolution, how sex in single-celled eukaryotes led to apoptosis in multi-cellular organisms, issues in tracking evolution using maternal mitochondrial DNA, why Aubrey de Gray's suggestion that we move mitochondrial DNA into our cell's nucleus as part of an anti-aging protocol won't work (when we can do the in-vivo gene manipulation), and how cells use reactive oxygen species as signals.The book explains a number of things I've wondered about:(1) Why does a mother's environment affect the children of her daughters? It's because the unit of growth is the cell, not just DNA, and the daughter's eggs are formed in-utero. So if the mother is stressed nutritionally early in the pregnancy, it affects her daughter's children by reducing the robustness of her daughter's eggs.(2) Why don't antioxidants increase longevity? It's because the cell uses ROS as a signal for proteins needed by the mitochondria and to grow more mitochondria, and needs a finely tuned level of internal anti-oxidant machinery in order to hear the signal, yet not be damaged by it. So taking extra Vitamin C or E reduce the internal signaling, and might cause premature apoptosis of the cell because it degrades the health of your mitochondria. This ties into studies showing that Vit C and/or E reduce the benefits of exercise, by shutting down the internal ROS signaling pathways.(3) How can we improve our own longevity? It looks like the major factor is the rate of leakage of ROS from mitochondria. So things that reduce this leakage make a big difference: (a) where possible, have your cells run on fat instead of glucose, because that reduces free electron leak from complex I, and (b) make sure you have balanced levels of omega-6 and omega-3 PUFA, as that appears to also make a significant difference (at least in mice...)There is much more, and I have a much better framework now for my research on how to optimize my health. Highly recommended!Two other books in the same class are The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor, and Cells, Gels and the Engines of Life.
I cannot exprese the gratitude I feel towards Nick Lane after reading this book. This is the best science book I've ever read in my life. (I'd like to study biology but don't have the means to)Everything: The format the book is written (it's divided in small sub chapters that you can read very quickly if you don't have time, i.e. in the morning instead of a newspaper article), the way Lane explains concepts (I even learned basic biology ideas I was never able to grasp), the way he presents the ideas itself...Power, Sex, Suicide gives me the same sense of awe and admiration that Cosmos gave me the first time I saw it. I'd really wish Lane was as famous as Sagan in terms of popularizing science.He (Lane) even presents ideas he doesn't agree with, which I really loved.I'm looking forward to buying Oxygen and of course as you can see now I'm a really huge, huge Lane's fan.
This book is a little hard to understand in places. I skip over paragraphs now and then. The subject is fascinating though.
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